P7854
Sigma
Anti-Presenilin-1 (S182) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
| MDL number: | MFCD02097229 |
Description
| Immunogen | synthetic peptide corresponding to the C-terminal of human presenilin-1 (amino acids 450-467 with N-terminally added lysine) conjugated to KLH. |
| Specificity | Specific for presenilin 1 (not found in presenilin 2) and is identical in mouse, rat, and Xenopus. By immunoblotting, the antibody reacts with presenilin 1 (PS1, S182) and with the PS1 cleavage product. |
| Physical form | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
Properties
| antibody form | IgG fraction of antiserum |
| clone | (polyclonal) |
| form | buffered aqueous solution |
| species reactivity | rat, human, mouse, Xenopus |
| application(s) | immunoblotting: 1:10,000 using whole cell extract of PC12 rat adrenal pheochromocytoma cell line |
| immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using methacarn-fixed, formic acid-treated sections of Alzheimer′s Disease (AD) brain | |
| microarray: suitable | |
| Gene Information | human ... PSEN1(5663) |
| rat ... Psen1(29192) | |
| mouse ... Psen1(19164) | |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | 3 |
Related Products
| Array | XP725, Panorama® Antibody Microarray - XPRESS Profiler725 Kit |
References
| reference | Octave, J., and Pitsi, D., Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity. J. Biol. Chem. 279, 25333-25338, (2004) Abstract |
